Developmental Perchlorate Exposure: Gilbert Responds

Developmental Exposure to Perchlorate Alters Synaptic Transmission in Hippocampus of the Adult Rat

BACKGROUND Perchlorate is an environmental contaminant that blocks iodine uptake into the thyroid gland and reduces thyroid hormones. This action of perchlorate raises significant concern over its effects on brain development. OBJECTIVES The purpose of this study was to evaluate neurologic function in rats after developmental exposure to perchlorate. METHODS Pregnant rats were exposed to 0,...

The Fallout from Fireworks: Perchlorate in Total Deposition

Recent studies have shown that natural perchlorate may be an important component to the general population exposure. These studies indicate that natural perchlorate is likely deposited by atmospheric deposition. Perchlorate concentration of total (dry + wet) deposition is relatively unstudied yet these measurements will aid in understanding natural levels in the environment. We sampled total de...

Developmental Perchlorate Exposure and Synaptic Transmission in Hippocampus

Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas

Perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. Our studies aimed to investigate the effects of concentrations of ammo...

The epidemiology of environmental perchlorate exposure and thyroid function: a comprehensive review.

OBJECTIVE To review the epidemiological literature relevant to evaluating the risk of adverse effects on thyroid function associated with environmental perchlorate exposure. METHODS All studies investigating possible adverse effects of environmental perchlorate exposure on thyroid function in adults or in pregnant women and their newborns were critically evaluated. RESULTS There is no credi...